A senescent liver is rejuvenated in a young systemic environment: A study based on comparison of chronological and biological ages. A senescent liver is rejuvenated in a young systemic environment: A study based on comparison of chronological and biological ages

Though the liver plays central roles in metabolism, the pivotal biological events throughout its aging are still unknown, resulting in ambiguity as to whether liver senescence could be reversed. To establish a criterion for liver-aging evaluation, dynamic hepatic biological features, including liver function, histology, transcriptional profile and protein expression, were screened in a cohort of Lewis rats at sequential chronological ages from 3 months to 24 months. Overall design: G1 (S3M-1, S3M-2, S3M-3), G2 (S9M-1, S9M-2, S9M-3), G3 (S12M-2, S12M-3, S12M-4), G4 (S18M-1, S18M-3, S18M-4) and G5 (S24M-1, S24M-2, S24M-3,S24M-4)

尽管肝脏在代谢过程中发挥核心作用，但其整个衰老进程中的关键生物学事件仍未明确，这使得肝脏衰老是否可逆转这一问题存在歧义。为建立肝脏衰老评估的标准，研究人员对从3月龄至24月龄的连续时序年龄段的Lewis大鼠（Lewis Rat）队列，筛选了包括肝功能、组织学特征、转录组谱及蛋白质表达在内的动态肝脏生物学特征。实验设计概况：G1组（S3M-1、S3M-2、S3M-3）、G2组（S9M-1、S9M-2、S9M-3）、G3组（S12M-2、S12M-3、S12M-4）、G4组（S18M-1、S18M-3、S18M-4）以及G5组（S24M-1、S24M-2、S24M-3、S24M-4）