CNAs affecting transcription factor binding sites that may affect CRC related genes.

A: TFBS in regions where the copy number changes in excess of +/−35% are marked on chromosomes 7 (gain), 14 (loss), 20 (short arm gain (males), loss (females), long arm gain (both sexes)), 21 (loss) and X (somewhat similar to chromosome 20). The marking is by the gene names corresponding to these TFBS. B: Association of TFBS genes with significant functions and C: pathways. Cancer and TGF-β signaling were statistically the most significant associations for these affected genes.

A: 拷贝数改变幅度超出±35%的区域内的转录因子结合位点（Transcription Factor Binding Site, TFBS）已在以下染色体完成标记：7号染色体（拷贝数扩增）、14号染色体（拷贝数缺失）、20号染色体（短臂：男性群体中扩增，女性群体中缺失；长臂：两性均发生扩增）、21号染色体（拷贝数缺失）以及X染色体（特征与20号染色体较为相似），标记方式为采用对应于这些转录因子结合位点的基因名称。
B: 转录因子结合位点关联基因与显著功能的关联
C: 转录因子结合位点关联基因与信号通路的关联
针对上述受影响基因，癌症相关通路与转化生长因子-β（Transforming Growth Factor-β, TGF-β）信号通路是统计学意义最显著的两类关联。