Atomistic Simulations of Electroporation in Water Preembedded Membranes

Atomistic simulations of electroporation were conducted on water/membrane/water systems, in which the membranes initially contained randomly distributed water molecules that might be introduced by acoustic treatment. The simulation results indicate that the critical strength of an applied electric field to induce electroporation is greatly reduced due to the initially embedded water molecules in the membranes. A lower applied electric field will significantly enhance the viability of cells in electroporation.

针对水-膜-水体系开展了电穿孔（electroporation）的原子级模拟（atomistic simulations），该体系中的膜初始时含有随机分布的水分子，此类水分子或通过声学处理引入。模拟结果表明，由于膜内初始嵌入的水分子，诱导电穿孔所需的外加电场临界强度大幅降低；更低的外加电场可显著提升电穿孔过程中细胞的存活率。