Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis

The goal of this study was to determine the developmental stage(s) and mechanisms by which Tropomyosin 1 impacts hematopoiesis. Genome-edited induced pluripotent stem cells were analyzed at the indicated time points during hematopoietic differentiation and compared to isogenic wild type controls. We analyzed 4 replicates at each time point.

本研究旨在明确原肌球蛋白1（Tropomyosin 1）影响造血过程的发育阶段及相关作用机制。本研究在造血分化过程中的指定时间点对基因组编辑诱导多能干细胞进行分析，并与同基因野生型对照样本进行比对。每个时间点均设置4次生物学重复开展分析。