Additional file 1 of eHealth supported multi-months dispensing of antiretroviral therapy: a mixed-methods preference assessment in rural Lesotho

Additional file 1: Supplementary Information. Data collection and processes. All eHealth options were implemented in the local language, Sesotho (Supplementary Figures 1 and 2). The VL result text messages containing encrypted information (minimize the risk of HIV status disclosure) were automatically triggered from a password protected online VL database. The automated interactive symptomatic TB screening call was triggered using tablet technology on site during enrolment. According to WHO recommendations, it encompasses requests for dialing 1=yes or 2=no for the presence of each of the symptoms, including coughing, fever, night sweats and weight loss, while the answers rely on self-assessment of the participants [31] For providing EAC support by telemedical service, an ART nurse was provided a list of participants, who came with recent VL ≥1000 copies/ml and who requested additional EAC by phone at their preferred time and day. For testing the nurse call-back, the phone number from the ART nurse was distributed to all participants during enrolment with the invitation to leave a missed phone call for requesting the call-back at any time. Supplementary Figure 1. Design of the automated VL result text messages. Supplementary Figure 2. Design of the automated symptomatic TB screening call.

附件1：补充材料。数据采集与处理流程。所有电子健康（eHealth）方案均采用当地语言塞索托语（Sesotho）开发实现（相关设计详见补充图1与补充图2）。包含加密信息（以降低HIV感染状态泄露风险）的病毒载量（Viral Load, VL）结果短信，将从受密码保护的在线VL数据库自动触发发送。在受试者入组阶段，通过现场平板设备触发自动化交互式症状性结核病（Tuberculosis, TB）筛查电话。依据世界卫生组织（WHO）的相关指南，该筛查流程要求受试者针对咳嗽、发热、盗汗及体重下降等每项症状，通过按键1表示“是”、按键2表示“否”进行作答，所有答案均由受试者自行评估完成[31]。为通过远程医疗服务提供增强依从性咨询（Enhanced Adherence Counselling, EAC）支持，向抗反转录病毒治疗（Antiretroviral Therapy, ART）护士提供了受试者名单，这些受试者近期病毒载量检测结果≥1000拷贝/毫升，且已通过电话提出在自选时段与日期接受额外EAC服务的请求。为测试护士回拨功能，入组阶段向所有受试者分发了该ART护士的联系电话，并邀请受试者可随时通过留下未接来电的方式发起回拨请求。补充图1：自动化VL结果短信设计方案。补充图2：自动化症状性结核病筛查电话设计方案。