Comparative Proteomic Signatures in Periodontitis: Saliva, Gingival Crevicular Fluid (GCF), Plaque, vs. Serum

Saliva, gingival crevicular fluid (GCF), and serum are common sources for studying host response and oral microbiota in periodontal patients. This cross-sectional study aimed to compare the proteomic signatures of periodontitis patients using full-mouth periodontal sampling with those obtained from serum and saliva samples. This study analysed proteome profiles from these biological sources in three systemically healthy, non-smoking patients with stage III, and grade C periodontitis.

唾液、龈沟液（gingival crevicular fluid, GCF）与血清，是研究牙周病患者宿主反应与口腔微生物组的常见样本来源。本横断面研究旨在对比采用全口牙周采样获取的牙周炎患者蛋白质组特征，与仅通过血清、唾液样本获得的蛋白质组特征。本研究针对3名全身健康、无吸烟史的III级C期牙周炎患者，分析了上述三类生物样本的蛋白质组谱。