Effectiveness of physical training on physical performance in patients with dermatomyositis and polymyositis: systematic review and meta-analysis

ABSTRACT This study aimed to evaluate the impact of physical training on physical performance in patients with dermatomyositis and polymyositis. For this purpose, we conducted a systematic review and meta-analysis according to the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The literature search was conducted in the following databases: PubMed/MEDLINE and Web of Science, using combinations of the following keywords in English: dermatomyositis OR polymyositis OR myositis AND exercise OR physical exercise OR physical therapy OR aerobic exercise OR endurance exercise OR resistance exercise. Studies that met the following criteria were included: (1) participants diagnosed with dermatomyositis or polymyositis; (2) patients that undergone a physical training protocol; (3) physical performance measured before and after the physical training protocol. A total of 14 articles were selected for inclusion in the systematic review and 10 articles were selected for inclusion in the meta-analysis. The outcomes demonstrate that physical training is effective in increasing overall physical performance in patients with dermatomyositis and polymyositis (effect size: 0.72; 95% CI 0.55; 0.89). Also, our study demonstrated that both the aerobic performance (effect size: 0.88; 95% CI 0.54; 1.21) and resistance performance variables (effect size: 0.64; CI 95% 0.43; 0.85) benefit from physical training in these patients. We concluded that physical training had a significant beneficial effect on the overall, aerobic and resistance physical performance in patients with dermatomyositis and polymyositis.

摘要 本研究旨在评估体能训练对皮肌炎(dermatomyositis)与多发性肌炎(polymyositis)患者躯体运动功能的影响。为此，我们依据PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses，系统评价与Meta分析首选报告条目)指南开展了系统评价与Meta分析。本研究在PubMed/MEDLINE及Web of Science数据库中进行文献检索，采用以下英文关键词组合：皮肌炎(dermatomyositis) OR 多发性肌炎(polymyositis) OR 肌炎(myositis) AND 运动 OR 体能训练(physical exercise) OR 物理治疗(physical therapy) OR 有氧运动(aerobic exercise) OR 耐力训练(endurance exercise) OR 抗阻训练(resistance exercise)。符合以下标准的研究将被纳入：(1) 研究对象确诊为皮肌炎或多发性肌炎；(2) 受试者接受了规范体能训练方案；(3) 在体能训练方案实施前后均对躯体运动功能进行了测评。本系统评价最终纳入14篇文献，Meta分析最终纳入10篇文献。研究结果显示，体能训练可有效提升皮肌炎与多发性肌炎患者的整体躯体运动功能（效应量(effect size)：0.72；95%置信区间(95% CI)：0.55~0.89）。此外，本研究还发现，此类患者的有氧运动能力（效应量：0.88；95%置信区间：0.54~1.21）与抗阻运动表现相关指标（效应量：0.64；95%置信区间：0.43~0.85）均可从体能训练中获益。综上，体能训练对皮肌炎与多发性肌炎患者的整体躯体运动功能、有氧运动能力及抗阻运动表现均具有显著的积极影响。