A cold stress-activated endocrine sentinel chemical hormone promotes insect survival via mitochondrial adaptations through the adipokinetic hormone receptor

Here, we identify the endogenous ascaroside C9 (asc-C9) acts as a chemical signal that markedly improves survival following acute cold exposure by coupling lipolysis to mitochondrial adaptation.本研究发现，内源性ascaroside C9（asc-C9）可作为一类化学信号分子，通过将脂解过程与线粒体适应性调控相偶联，显著提升生物体在急性冷暴露后的存活率。