Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43729
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资源简介：
Gene Expression profiling of HSCs isolated at different stages of ontogeny to address correlation between gene expression and changes in DNA methylation Gene expression profiling of hematopoietic stem cells isolated from e14.5 fetal liver (lineage- ckit+ sca1+CD150+ CD48- Mac1+), 3 month old mice (lineage- ckit+ sca1+ CD34- Flk2-) and 25 month old mice (lineage- ckit+ sca1+ CD34- Flk2-)
为探究基因表达与DNA甲基化变化之间的相关性，本数据集针对不同发育阶段分离得到的造血干细胞（hematopoietic stem cells，HSCs）开展基因表达谱分析。所纳入分析的造血干细胞分别分离自：e14.5胎肝（细胞表型为lineage- ckit+ sca1+CD150+ CD48- Mac1+）、3月龄小鼠（细胞表型为lineage- ckit+ sca1+ CD34- Flk2-）以及25月龄小鼠（细胞表型为lineage- ckit+ sca1+ CD34- Flk2-）
创建时间：
2019-02-11
