Transciptome profile of regulatory T cells during Trypanosoma cruzi experimental infection

Trypanosoma cruzi is the etiologic agent of Chagas' disease. During this infection, exuberant immune responses have been associated with susceptibility to infection and development of immunopathology in humans and mouse models. A profound analysis of the regulatory arm of the immune system is key to understand disease outcome during Trypanosoma cruzi's infection.

克氏锥虫（Trypanosoma cruzi）是恰加斯病（Chagas' disease）的致病病原体。在该感染进程中，过度免疫应答与人类及小鼠模型中的感染易感性和免疫病理损伤的发生发展密切相关。深入剖析免疫系统的调节分支，是理解克氏锥虫感染后疾病转归的关键所在。