Ocular Manifestations of Psoriasis: A Systematic Review

Psoriasis, a chronic inflammatory skin disease, manifests itself by an array of immunological and inflammatory alterations. Ocular involvement can occur through a variety of pathways, notably direct interaction with psoriatic plaques or psoriasis-associated inflammatory responses. The present systematic review was intended to more effectively comprehend and describe the prevalent nature of psoriasis ocular symptoms by tracking all relevant studies published over the last decade and carefully synthesizing their findings. This systematic review was performed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for study selection, synthesis, and reporting of results. The PubMed, Cochrane, and Scopus databases were used to search for evidence-based research papers on psoriasis ocular symptoms published between January 2012 and August 2023. The prevalence of ocular manifestations in psoriasis varied between the studies ranging from 81.4% to 10%. The increase in the ocular symptoms with prolonged duration of psoriasis was statistically significant. Dry eye condition is the most prevalent clinical ocular alteration related to psoriasis. Blepharitis, conjunctivitis, keratopathy, and uveitis were common in psoriasis patients. Higher intraocular pressure and glaucoma were reported. Physicians should keep in mind and look for ocular associations in Psoriasis patients. Addressing the crucial stages in the pathophysiology of ocular alterations is essential for targeted efforts for immunotherapeutic management. Interventions are shifting away from broad immunosuppression towards the administration of particular biologicals that target specific components of the immune response.

银屑病（Psoriasis）是一种慢性炎症性皮肤病，其特征表现为一系列免疫及炎症性改变。眼部受累可通过多种途径发生，尤其是与银屑病斑块的直接接触或银屑病相关的炎症反应。本系统综述旨在通过追踪过去十年发表的所有相关研究并仔细综合其结果，更有效地理解和描述银屑病眼部症状的流行特征。

本系统综述遵循系统综述与荟萃分析优先报告条目（Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA）指南进行研究选择、综合及结果报告。研究人员使用PubMed、Cochrane和Scopus数据库检索了2012年1月至2023年8月发表的关于银屑病眼部症状的循证研究论文。

不同研究中银屑病眼部表现的患病率差异较大，范围在10%至81.4%之间。银屑病病程延长时眼部症状的增加具有统计学意义。干眼症是银屑病相关的最常见临床眼部改变。睑缘炎、结膜炎、角膜病变和葡萄膜炎在银屑病患者中较为常见。研究还报告了眼压升高及青光眼的情况。

临床医生应注意并排查银屑病患者的眼部相关病变。明确眼部改变病理生理学中的关键阶段，对于针对性免疫治疗管理至关重要。目前干预措施正从广泛的免疫抑制转向使用靶向免疫反应特定成分的特定生物制剂。