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Development of probiotics for inflammatory bowel disease using novel biomarker based screening tool and gnotobiotic mouse model. Lactic acid bacteria

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NIAID Data Ecosystem2026-03-14 收录
下载链接:
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA949423
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资源简介:
Establishment of gnotobiotic mouse facilityScreening of probiotic candidates using in vitro (cell lines and gut fermenation system) and in vivo (DSS-induced colitis mouse model) systemValidation of probiotic efficacy and mechanism for the treatment of anti-inflammatory and microbiota-modulatory functions using multi-omics analysis

悉生小鼠(gnotobiotic mouse)设施的建立;采用体外(细胞系与肠道发酵系统)与体内(葡聚糖硫酸钠(DSS)诱导的结肠炎小鼠模型)体系筛选益生菌候选菌株;通过多组学分析验证益生菌的抗炎与菌群调节功能的治疗功效及作用机制
创建时间:
2023-03-28
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