Somatic Mosaicism across Human Tissues (SMaHT)
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https://registry.opendata.aws/smaht
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资源简介：
The Somatic Mosaicism across Human Tissues (SMaHT) project is an NIH Common Fund consortium (2023-) aimed to comprehensively characterize somatic variation ("mosaicism") in normal human tissues. While most genetic studies have relied on blood-derived DNA, SMaHT captures the full spectrum of DNA variation across cell types, tissues, and organs from phenotypically normal individuals to better understand the role of somatic mosaicism in human development, aging, and disease progression.Researchers in the consortium develop and apply experimental and computational methods, paired with th...
人类组织体细胞嵌合度（Somatic Mosaicism across Human Tissues, SMaHT）项目是美国国立卫生研究院（National Institutes of Health, NIH）共同基金资助的科研联盟（2023年至今），旨在全面解析正常人类组织中的体细胞变异（即体细胞嵌合，somatic mosaicism）。尽管绝大多数遗传学研究均依赖血液来源的DNA，但SMaHT项目获取了表型正常个体中不同细胞类型、组织与器官的全谱系DNA变异特征，以深入阐明体细胞嵌合现象在人类发育、衰老及疾病进展中的作用。该联盟的研究人员开发并应用实验与计算方法，并结合……
提供机构：
SMaHT Data Analysis Center (DAC)
