Salinispora arenicola CNX481

Multiplexed sequencing for secondary metabolite discovery: the goal of this project is to generate draft genome sequences for 144 or more cultured marine actinomycetes. The focus is on the genus Salinispora, which has proven to be a rich source of unusual secondary metabolites. Multiple strains derived from different locations will provide opportunities to assess the secondary metabolome of a well-defined bacterial lineage and to better understand pathway evolution and how it generates structural complexity. This project provides a unique opportunity to apply genome-mining approaches to natural product discovery and to use population genomics to explore fundamental questions related to the ecology and evolution of bacteria.

用于次生代谢产物发掘的多重测序研究：本项目的目标是为144株及以上已培养的海洋放线菌（marine actinomycetes）绘制草图基因组序列。本项目的研究重点为盐孢菌属（Salinispora），该属已被证实是非常规次生代谢产物的优质资源库。分离自不同采样地点的多株菌株，将为解析一类定义明确的细菌谱系的次生代谢组（secondary metabolome）提供契机，并助力我们深入解析代谢通路的演化过程及其如何造就结构多样性。本项目为将基因组挖掘（genome-mining）策略应用于天然产物发掘，以及运用群体基因组学（population genomics）探究细菌生态学与演化相关的基础科学问题提供了独特机遇。