NHLBI TOPMed: Genetics of Asthma in Latino Americans (GALA)

This is a case pharmacogenetic study of bronchodilator drug response (Albuterol) among racially admixed Latino children with asthma between the ages of 8-40. Lung function testing was performed using the KoKo PFT system and each participant was administered albuterol dependent on age. Participants under 16 years of age, were administered 2 puffs of albuterol from a standard metered dose inhaler and 4 puffs for participants over 16 years old.

The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants with asthma have physician-diagnosed asthma, symptoms and medications.

本研究为一项针对8至40岁种族混合拉丁裔哮喘儿童的支气管扩张剂（bronchodilator）药物应答（沙丁胺醇（Albuterol））的病例药物基因组学研究。研究采用KoKo肺功能检测系统（KoKo PFT system）开展肺功能检测，受试者根据年龄接受沙丁胺醇给药：16岁以下受试者经标准定量吸入器吸入2喷沙丁胺醇，16岁以上受试者则吸入4喷。
本研究的总体目标是鉴定可预测哮喘儿童药物应答的遗传因素。核心研究手段包括问卷调查与生物样本采集。入组的哮喘受试者均经医师确诊哮喘，且存在哮喘症状及用药史。