Identification of specific ceRNA signatures in prostate cancer (PCa). Identification of specific ceRNA signatures in prostate cancer (PCa)

In order to develop novel biomarkers in prostate cancer, we applied a competing endogenous RNA (ceRNA) microarray to identify differentially expressed mRNAs, circRNAs and lncRNAs in PCa tissue. Overall design: Four pairs of prostate cancer and paracancerous tissues were used for the microarray assay to investigate the differentially expressed mRNAs, circRNAs and lncRNAs between the tumor tissues and paracancerous tissues

为开发前列腺癌新型生物标志物，本研究采用竞争性内源RNA（competing endogenous RNA，ceRNA）微阵列技术，鉴定前列腺癌组织中差异表达的mRNA、circRNA及lncRNA。整体实验设计：我们选取4对前列腺癌组织及配对癌旁组织进行微阵列检测，以探究肿瘤组织与癌旁组织间的差异表达mRNA、circRNA及lncRNA。