Blood DNA methylation profiles from first episode psychosis patients and controls I. Blood DNA methylation profiles from first episode psychosis patients and controls I

Genome-wide patterns of DNA methylation were quantified using the Illumina Infinium HumanMethylationEPIC BeadChip (“EPIC array”) in DNA samples isolated from blood for schizophrenia cases, first episode psychosis patients and controls. These samples were profiled as part of a wider study where they were meta-analysed with other cohorts. Overall design: This data includes 934 adult samples profiled as part of a psychosis case control study design. Specifically it includes data for 458 first-episode psychosis (FEP) cases and 558 controls recruited as part of the EU-GEI study.

本研究采用Illumina Infinium人类甲基化EPIC芯片（Illumina Infinium HumanMethylationEPIC BeadChip），对精神分裂症患者、首发精神病患者及健康对照者的血液来源DNA样本开展全基因组DNA甲基化模式定量检测。上述样本作为一项更大规模研究的组成部分完成表观分型，并与其他队列进行荟萃分析。
整体实验设计：本数据集包含934例成人样本，均为精神病病例对照研究的分型样本。具体而言，其中包含EU-GEI研究招募的458例首发精神病（first episode psychosis, FEP）患者与558例健康对照者的相关数据。