DataSheet_5_Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17.zip

The role of long non-coding RNA (lncRNA) in human tumors has gradually received increasing attention in recent years. Particularly, the different functions of lncRNAs in different subcellular localizations have been widely investigated. The upregulation of lncRNA small nucleolar RNA host gene 17 (SNHG17) has been observed in various human tumors. Growing evidence has proved that SNHG17 plays a tumor-promoting role in tumorigenesis and development. This paper describes the molecular mechanisms by which SNHG17 contributes to tumor formation and development. The different functions of SNHG17 in various subcellular localizations are also emphasized: its function in the cytoplasm as a competing endogenous RNA (ceRNA), its action in the nucleus as a transcriptional coactivator, and its function through the polycomb repressive complex 2 (PRC2)-dependent epigenetic modifications that regulate transcriptional processes. Finally, the correlation between SNHG17 and human tumors is summarized. Its potential as a novel prognostic and diagnostic biomarker for cancer is explored especially.

长链非编码RNA（long non-coding RNA，lncRNA）在人类肿瘤中的作用近年来逐渐受到学界的广泛关注。尤为值得关注的是，lncRNA在不同亚细胞定位中的功能差异已得到广泛研究。小核仁RNA宿主基因17（small nucleolar RNA host gene 17，SNHG17）的上调现象已在多种人类肿瘤中被观测到，越来越多的研究证据表明，SNHG17在肿瘤发生与发展进程中发挥促癌作用。本文系统阐述了SNHG17促进肿瘤形成与发展的分子机制，并着重强调了其在不同亚细胞定位中的功能差异：其在细胞质中可作为内源竞争RNA（competing endogenous RNA，ceRNA）发挥功能，在细胞核中可作为转录辅激活子行使作用，还可通过依赖于多梳抑制复合体2（polycomb repressive complex 2，PRC2）的表观遗传修饰调控转录过程。最后，本文总结了SNHG17与人类肿瘤的相关性，并着重探讨了其作为新型癌症预后与诊断生物标志物的潜在价值。