Table_1_TOMM34 serves as a candidate therapeutic target associated with immune cell infiltration in colon cancer.xls

BackgroundColon cancer represents one of the most pervasive digestive malignancies worldwide. Translocase of the outer mitochondrial membrane 34 (TOMM34) is considered an oncogene and is implicated in tumor proliferation. However, the correlation between TOMM34 and immune cell infiltration in colon cancer has not been investigated.
Materials and methodsBased on multiple open online databases, we performed integrated bioinformatics analysis of TOMM34 to evaluate the prognostic value of TOMM34 and its correlation with immune cell infiltration.
ResultsTOMM34 gene and protein expression levels were elevated in tumor tissues compared with normal tissues. Survival analysis revealed that upregulation of TOMM34 was significantly associated with poorer survival time in colon cancer. High TOMM34 expression was dramatically related to low levels of B cells, CD8+ T cells, neutrophils, dendritic cells, PD-1, PD-L1 and CTLA-4.
ConclusionsOur results confirmed that high expression of TOMM34 in tumor tissue correlates with immune cell infiltration and worse prognosis in colon cancer patients. TOMM34 may serve as a potential prognostic biomarker for colon cancer diagnosis and prognosis prediction.

背景：结肠癌是全球范围内最普遍的消化系恶性肿瘤之一。线粒体外膜转位酶34（Translocase of the outer mitochondrial membrane 34，TOMM34）被认为是一种癌基因，与肿瘤增殖过程密切相关。然而，目前尚未有研究探讨TOMM34与结肠癌免疫细胞浸润之间的关联。
材料与方法：本研究基于多个公开在线数据库，对TOMM34开展整合生物信息学分析，以评估其预后价值及其与免疫细胞浸润的相关性。
结果：与正常组织相比，肿瘤组织中TOMM34的基因及蛋白表达水平均显著升高。生存分析显示，TOMM34高表达与结肠癌患者更短的生存时间显著相关。TOMM34高表达与B细胞、CD8+ T细胞、中性粒细胞、树突状细胞、PD-1、PD-L1及CTLA-4的低水平表达显著相关。
结论：本研究结果证实，结肠癌组织中TOMM34高表达与免疫细胞浸润及患者不良预后密切相关。TOMM34有望成为结肠癌诊断及预后预测的潜在预后生物标志物。