Table 1_Demonstrating public health impacts of translational science at the clinical and translational science collaborative (CTSC) of northern Ohio: a mixed-methods approach using the translational science benefits model.docx

The Clinical and Translational Science Award (CTSA) program, funded by the National Center for Advancing Translational Sciences (NCATS), aims to accelerate the translation of research into public health impacts. However, measuring the societal impact of translational research poses challenges due to extended timelines for implementation. This study uses the Translational Science Benefits Model (TSBM) to evaluate the societal impact of CTSA-supported research at the Clinical and Translational Science Collaborative (CTSC) of Northern Ohio at Case Western Reserve University (CWRU). Using the TSBM, we asked how investigators have used the CTSC to demonstrate translational science impacts in public health practice both domestically and internationally. Using a mixed methods approach, this study analyzed TSBM-based survey data from CTSC-supported KL2 Scholars and Pilot Program awardees, along with key publications and interviews, to document societal benefits across four TSBM domains: Clinical & Medical, Community & Public Health, Economic, and Policy & Legislative. Findings demonstrate that CTSC-supported research improved public health by enhancing healthcare access, improving health outcomes, informing policy, and generating economic benefits. These impacts span local, national, and global contexts. By applying a mixed methods approach, we demonstrate the value of using the TSBM not just as an evaluative framework, but as a strategic tool for capturing the real-world significance of translational science. This approach strengthens the ability of CTSA hubs to highlight the broader public value of their work, reinforcing the CTSA program’s mission to transform scientific discoveries into lasting health and societal benefits.

由美国国家转化科学推进中心（National Center for Advancing Translational Sciences, NCATS）资助的临床与转化科学奖（Clinical and Translational Science Award, CTSA）计划，旨在加速科研成果向公共卫生效益的转化。然而，由于转化研究的实施周期较长，衡量其社会影响面临诸多挑战。本研究依托转化科学效益模型（Translational Science Benefits Model, TSBM），对凯斯西储大学（Case Western Reserve University, CWRU）北俄亥俄临床与转化科学协作组（Clinical and Translational Science Collaborative, CTSC）所资助的CTSA项目研究的社会影响展开评估。本研究旨在探究研究者如何借助CTSC平台，在国内外公共卫生实践中论证转化科学的实际效益。本研究采用混合研究方法，分析了CTSC资助的KL2学者与试点项目受助者的TSBM相关调研数据，辅以关键文献与访谈记录，从TSBM划定的四大领域——临床与医学、社区与公共卫生、经济、政策与立法——梳理其社会增益。研究结果表明，受CTSC资助的科研项目通过改善医疗可及性、优化健康结局、为政策制定提供科学依据以及创造经济收益，切实推动了公共卫生事业发展，其影响覆盖本地、全国乃至全球范围。本研究通过混合研究方法证实，转化科学效益模型不仅可作为标准化评估框架，更可作为捕捉转化科学现实应用价值的战略工具。该方法能够强化CTSA中心展示其研究更广范围公共价值的能力，助力CTSA计划实现将科学发现转化为持久健康福祉与社会收益的核心使命。