Characterization of Streptococcus pneumoniae isolates obtained from the middle ear fluid of US children, 2011-2021

Pneumococcal conjugate vaccines (PCVs), including higher valency vaccines such as PCV20, have the potential to reduce pediatric otitis media. We assessed serotype distribution, potential PCV coverage, and antimicrobial susceptibility of Streptococcus pneumoniae isolates cultured from middle ear fluid (MEF) of US children age 5 years and younger.

肺炎球菌结合疫苗（Pneumococcal Conjugate Vaccines，PCVs），包括PCV20等多价疫苗，有望降低儿童中耳炎的发病风险。本研究针对从5岁及以下美国儿童中耳积液（middle ear fluid, MEF）中分离得到的肺炎链球菌（Streptococcus pneumoniae）菌株，对其血清型分布、PCV潜在覆盖范围以及抗菌药物敏感性进行了评估。