Expression data from HER2+ breast cancer cell lines.. Expression data from HER2+ breast cancer cell lines.

miRNA expression is often disregulated in cancer pathways, such as progression of resistance. We used microarrays in order to determine the differences in miRNA expression between breast cancer cell lines and their resistant pairs. Overall design: We analysed two different cell lines (BT474 and SKBR3) compared to their induced resistant cell lines (BT474r and SKBR3r). Each of the four cell lines was analysed by triplicate.

微小RNA（microRNA, miRNA）的表达常在癌症通路中发生失调，例如耐药性的进展过程。本研究采用基因微阵列（microarrays）技术，旨在探究乳腺癌细胞系与其耐药配对细胞系之间的微小RNA表达差异。整体实验设计：本研究选取两种不同的乳腺癌细胞系（BT474与SKBR3），分别与其诱导产生的耐药细胞系（BT474r与SKBR3r）进行对比分析；四种细胞系均设置三次重复实验。