Drosophila TDP-43 RNA-binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers, and Polycomb Response Elements. Drosophila melanogaster

Binding of sister chromatid cohesion and RNA-bindng proteins to chromosomes was measured by ChIP-seq Overall design: Comparison of binding of sister chromatid cohesion and RNA-binding proteins in untreated (Mock) cells and cells RNAi depleted for sister chromatid cohesion and RNA-binding proteins

本研究通过染色质免疫共沉淀测序（ChIP-seq）检测了姐妹染色单体黏连（sister chromatid cohesion）相关蛋白与RNA结合蛋白（RNA-binding proteins）在染色体上的结合情况。
实验设计概述：对比未处理（Mock）细胞与经RNA干扰（RNAi）敲低姐妹染色单体黏连及RNA结合蛋白的细胞中，两类蛋白的染色体结合水平差异。