Hepatitis B virus genotypes prevalence in patients from hepatology services in Ceará, Brazil

Abstract INTRODUCTION: Hepatitis B virus (HBV) infection is a public health problem; therefore, we aimed to report HBV genotypes in Ceará, Brazil. METHODS: A total of 103 HBsAg-positive samples were subjected to HBV genotyping and subgenotyping. RESULTS: The following genetic compositions of samples were found: F-54% (F2-83.33%), A-40% (A1-65%), D-6%, C2-1%, E-1%, and G-1%. CONCLUSIONS: Some genotypes are only prevalent in certain parts of the world; however, the State of Ceará is a hub for migration and has one of the most important liver transplantation centers in Brazil, which can explain the prevalence of the F genotype.

【摘要】
引言：乙型肝炎病毒（Hepatitis B virus, HBV）感染是一项公共卫生问题，因此本研究旨在报告巴西塞阿拉州的HBV基因型分布情况。
方法：本研究共纳入103份乙型肝炎表面抗原（HBsAg）阳性样本，对其开展HBV基因分型与亚型分型检测。
结果：本次检测得到的样本基因构成如下：F型占54%（其中F2亚型占83.33%）、A型占40%（其中A1亚型占65%）、D型占6%、C2型占1%、E型占1%以及G型占1%。
结论：部分基因型仅在全球特定区域流行，但塞阿拉州作为移民枢纽，且拥有巴西最重要的肝移植中心之一，这可解释该地区F基因型的高流行态势。