Ribosome profiling reveal the unfolded protein response as a central regulator of pigeon lactation

This study examines crop sacs from 225-day-old unpaired, non-lactating male pigeons (MN) alongside males that initiated lactation on the first day after incubation (ML). Through ribosome profiling, we observed a significant upregulation of genes linked to ribosome assembly and protein synthesis in ML samples compared to MN.本研究以225日龄未配对、未泌乳的雄性鸽子（MN），以及孵化后首日启动泌乳的雄性鸽子（ML）的嗉囊（crop sacs）为研究材料；通过核糖体谱分析（ribosome profiling）发现，相较于MN组样本，ML组样本中与核糖体组装及蛋白质合成相关的基因呈现显著上调表达。