Table1_Construction and Validation of a Novel Pyroptosis-Related Gene Signature to Predict the Prognosis of Uveal Melanoma.docx

Uveal melanoma is the most common primary intraocular tumor with a poor prognosis. Currently, treatment for UVM is limited, and the development of drug resistance and tumor recurrence are common. Therefore, it is important to identify new prognostic biomarkers of UVM and explore their role in the tumor microenvironment. Pyroptosis is a way of cell programmed death, and related research is in full throttle. However, the role of pyroptosis in UVM is unclear. In this study, we constructed the prognosis model of pyroptosis-related genes of UVM. This model can accurately guide the prognosis of UVM, and different groups differ in immune infiltration. We further verified our results in cell experiments. To some extent, our study can provide new ideas for the diagnosis and treatment of UVM.

葡萄膜黑色素瘤（Uveal melanoma，以下简称UVM）是最常见的原发性眼内肿瘤，预后较差。目前UVM的治疗手段十分有限，耐药性与肿瘤复发较为常见。因此，鉴定UVM新型预后生物标志物并探索其在肿瘤微环境中的作用具有重要意义。细胞焦亡（Pyroptosis）是一种程序性细胞死亡方式，相关研究正处于热潮之中，但细胞焦亡在UVM中的作用尚不明确。本研究构建了UVM细胞焦亡相关基因预后模型，该模型可精准指导UVM患者的预后分层，且不同风险组的免疫浸润状态存在显著差异。研究团队进一步通过细胞实验对研究结果进行了验证。本研究在一定程度上可为UVM的诊断与治疗提供全新思路。