Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1

Long non-coding RNA RGMB-AS1 (RGMB antisense RNA 1) plays a crucial role in tumor progression. However, its underlying mechanism in nasopharyngeal carcinoma (NPC) remains unclear. In this study, we analyzed the clinical significance of lncRNA RGMB-AS1 as a possible potential marker in NPC, and investigated the effect and mechanism of lncRNA RGMB-AS1 on proliferation, migration and epithelial mesenchymal transformation (EMT) of NPC by directly binding Forkhead box A1 (FOXA1) in vitro and in vivo. In conclusion, LncRNA RGMB-AS1 inhibits malignant behaviors and EMT by regulating FOXA1, and lncRNA RGMB-AS1 may be an important indicator of clinical prognosis.

长链非编码RNA（long non-coding RNA, lncRNA）RGMB-AS1（RGMB反义RNA 1）在肿瘤进展中发挥关键作用。然而，其在鼻咽癌（nasopharyngeal carcinoma, NPC）中的潜在作用机制仍未阐明。本研究分析了lncRNA RGMB-AS1作为鼻咽癌潜在临床标志物的意义，并通过体内外实验探究了lncRNA RGMB-AS1通过直接结合叉头框蛋白A1（Forkhead box A1, FOXA1）对鼻咽癌细胞增殖、迁移及上皮间质转化（epithelial mesenchymal transformation, EMT）的影响与作用机制。综上，lncRNA RGMB-AS1可通过调控FOXA1抑制鼻咽癌细胞的恶性行为与上皮间质转化，其或可成为临床预后评估的重要指标。