Organoid phenotypic testing identifies IFN-beta as neuroprotective compound against ZIKA virus (ZIKV). Organoid phenotypic testing identifies IFN-beta as neuroprotective compound against ZIKA virus (ZIKV)

Administration of recombinant interferons to 3D brain organoid cultures infected with ZIKV identifies IFN-beta as compound that alleviates organoid damage and inhibits ZIKV Overall design: Comparison of transcriptomes from ZIKV infected or MOCK organoids treated with IFN-alpha or IFN-beta or left untreated (6 conditions) at two time points

向寨卡病毒（ZIKV）感染的三维脑类器官培养体系中施加重组干扰素，可筛选鉴定出β干扰素（IFN-β）作为可缓解类器官损伤并抑制寨卡病毒的化合物。实验整体设计：在两个时间点下，对涵盖6种实验条件的样本进行转录组对比分析，这些样本分别为经α干扰素（IFN-α）、β干扰素（IFN-β）处理或未处理的寨卡病毒感染与模拟感染（MOCK）类器官。