Mucosal effects of tenofovir 1% gel wane over longer-term use but retain pro-proliferative and type I/III interferon pathway signatures: Proteomics from MTN014

The purpose of this data set was to measure how the expression of proteins in rectal biopsies is affected by use of topical tenofovir gel for prevention of HIV infection. Proteins were measured by mass spectrometry from samples taken from the MTN-014 study at baseline and after two weeks of rectal or vaginal gel application.In the raw_data tab, each row is a sample. There are several columns describing each sample and then many columns containing the expression level for each detected protein. Expression levels were adjusted for batch effects using ComBat.In the data_dictionary tab, the columns of the raw_data tab are explained.In the protein_lookup tab, there is one row per protein detected, mapping from UniProt ID to gene symbol and Entrez Gene ID.

本数据集旨在测定局部用替诺福韦凝胶用于HIV感染预防时，直肠活检样本中蛋白质的表达受其影响的情况。蛋白质表达水平通过质谱法（mass spectrometry）测定，样本来源于MTN-014研究中基线期及直肠或阴道凝胶施用两周后的受试者。

在raw_data表中，每一行代表一个样本，包含若干描述样本的列，以及大量对应各检测蛋白质表达水平的列。表达水平已通过ComBat算法（ComBat）校正批次效应（batch effects）。

在data_dictionary表中，对raw_data表的各列进行了解释说明。

在protein_lookup表中每一行对应一个检测到的蛋白质，提供了从UniProt ID到基因符号及Entrez Gene ID的映射关系。