Correlation Between the Computed Tomography and 3D Scanning System-Based Periorbital Morphology of Children with Congenital Microphthalmia

This article aimed to explore the correlation between the periorbital morphology determined using a 3D scanning system and CT in congenital microphthalmia.
Fifty-two children with microphthalmia aged 0–6 were enrolled in this study. All the participants were subjected to orbital CT scans and 3D scanning. The CT and 3D scanning images were separately processed to obtain the orbital and facial parameters. Multivariate regression was used to analyze the correlation between 3D parameters and orbital volume.
The orbital volume of the affected side (15.25 ± 3.35 cm3) was generally smaller than the unaffected side (18.58 ± 2.65 cm3, p < .001). Based on CT, at all ages, the parameters of the unaffected orbit were greater than the affected side. In the 3D scanning and 3D reconstruction based on CT, both unaffected and affected sides were highly correlated. A multiple linear regression equation including three 3D scanning factors was obtained for the orbital volume (R2 = 0.808, p < .001).
The retarded orbital volume could be estimated by the parameters based on 3D scanning, along with axial length. In the follow-up stage, 3D scanning can be a novel alternative method to assess the degree of orbital growth retardation in congenital microphthalmia.

本研究旨在探讨基于3D扫描系统与计算机断层扫描（CT）所获取的先天性小眼球患者眶周形态学特征的相关性。
本研究纳入52名年龄0~6岁的小眼球患儿，所有受试者均接受眼眶CT扫描与3D扫描。分别对CT图像与3D扫描图像进行处理以提取眼眶及面部相关参数，并采用多元回归分析3D参数与眼眶容积的相关性。
患侧眼眶容积（15.25±3.35 cm³）整体小于健侧（18.58±2.65 cm³，p<0.001）。基于CT成像结果，各年龄段健侧眼眶的各项参数均大于患侧。在3D扫描以及基于CT的3D重建结果中，健侧与患侧的各项参数均呈现高度相关性。最终构建包含3项3D扫描参数的眼眶容积多元线性回归方程（R²=0.808，p<0.001）。
可通过3D扫描获取的参数与眼轴长度对眼眶容积发育迟缓程度进行估算。
在随访阶段，3D扫描可作为评估先天性小眼球患者眼眶发育迟缓程度的新型替代方法。