General Method for Synthesis of 2-Heterocyclic <i>N</i>-Methyliminodiacetic Acid Boronates

A wide range of 2-pyridyl and other difficult-to-access heterocyclic N-methyliminodiacetic acid boronates can be readily prepared from the corresponding bromides via a new method involving direct transligation of 2-heterocyclic trialkoxyborate salts with N-methyliminodiacetic acid (MIDA) at elevated temperatures.多种2-吡啶基及其他难以获取的杂环N-甲基亚氨基二乙酸硼酸酯，可通过一种全新方法由相应溴代物便捷制备。该方法在高温条件下，使2-杂环三烷氧基硼酸盐与N-甲基亚氨基二乙酸（N-methyliminodiacetic acid, MIDA）发生直接转配反应。