FLANC, a novel primate-specific long non-coding RNA, is involved in colorectal carcinogenesis and holds potential as a novel therapeutic target (overexpression)

FLANC is significantly up-regulated in two cohorts of CRC samples and high level of FLANC is associated with poor patient survival in two additional independent cohorts. FLANC influences cellular growth, apoptosis, migration and metastases formation of CRC cells. We performed genome-wide microarray expression profiling to study the genetic landscape alterations induced by the overexpression of FLANC in HCT-116 cells.

FLANC在两队列结直肠癌（Colorectal Cancer, CRC）样本中呈现显著上调表达，且在另外两个独立队列中，FLANC的高表达与结直肠癌患者的不良生存预后显著相关。FLANC可调控结直肠癌细胞的增殖、凋亡、迁移及转移灶形成能力。本研究通过全基因组微阵列表达谱分析技术，探究了HCT-116细胞中FLANC过表达所诱导的遗传全景改变。