Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide Descriptor: 2-amino-4-{2,4-dichloro-6-[2-(1H-pyrazol-1-yl)ethoxy]phenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide, Heat shock protein HSP 90-alpha, PHOSPHATE ION Authors: Gajiwala, K.S. Deposit date: 2011-03-17 Release date: 2011-04-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide. J.Med.Chem., 54, 2011

针对热休克蛋白90（heat shock protein 90, HSP90）的强效、选择性且具有口服生物利用度的含吡咯并嘧啶（pyrrolodinopyrimidine）抑制剂的优化：开发候选化合物2-氨基-4-{4-氯-2-[2-(4-氟-1H-吡唑-1-基)乙氧基]-6-甲基苯基}-N-(2,2-二氟丙基)-5,7-二氢-6H-吡咯并[3,4-d]嘧啶-6-甲酰胺
描述项：2-氨基-4-{2,4-二氯-6-[2-(1H-吡唑-1-基)乙氧基]苯基}-N-(2,2-二氟丙基)-5,7-二氢-6H-吡咯并[3,4-d]嘧啶-6-甲酰胺、热休克蛋白HSP 90-α（Heat shock protein HSP 90-alpha）、磷酸根离子（PHOSPHATE ION）
作者：Gajiwala, K.S.
存储日期：2011-03-17
发布日期：2011-04-27
最后修改日期：2024-02-21
检测方法：X射线衍射（X-RAY DIFFRACTION，1.7 Å）
引用文献：《强效、选择性且具有口服生物利用度的含吡咯并嘧啶热休克蛋白90抑制剂的优化：开发候选化合物2-氨基-4-{4-氯-2-[2-(4-氟-1H-吡唑-1-基)乙氧基]-6-甲基苯基}-N-(2,2-二氟丙基)-5,7-二氢-6H-吡咯并[3,4-d]嘧啶-6-甲酰胺》，《药物化学杂志》（J.Med.Chem.），第54卷，2011年