Linear regression model with MBI score.

Aim
To analyze the relationship between burnout syndrome, cognitive functions, and sBDNF (Serum Brain-derived Neurotrophic Factor) in Mexican nurses.
Method
A descriptive cross-sectional design was used. This study target staff nurses working in hospitals in Guanajuato, México. Demographic and working condition data were collected via questionnaire. The Maslach Burnout Inventory (MBI) was used to evaluate burnout. A blood sample were collected and processed by ELISA technique to measure sBDNF. Finally, the General Cognitive Assessment (CAB) of the Cognifit© neuropsychological battery was used to evaluated cognitive functions.
Results
Findings showed that there are sociodemographic characteristics and working conditions associated with burnout syndrome among nurses. Furthermore, the data demonstrated a significant decrease in sBDNF levels in burnout nurses and a negative correlation between BDNF levels and burnout syndrome. Additionally, these burnout nurse also revealed significant cognitive impairment in reasoning, memory, and attention as well as total scores of CAB. Interestingly, we found a positive correlation between sBDNF levels and the cognitive deficits in burnout nurse.
Conclusion
Reduced BDNF levels could be a biological indicator or part of the pathological process of burnout, which could affect cognitive abilities. Reduced cognitive function in nurses has relevant implications and emphasizes the need for specialized preventive strategies because nurses make clinical decisions concerning their patients, whose situations are constantly changing.

研究目的
本研究旨在分析墨西哥护士的职业倦怠综合征、认知功能与血清脑源性神经营养因子（sBDNF, Serum Brain-derived Neurotrophic Factor）之间的关联。

研究方法
本研究采用描述性横断面研究设计，研究对象为墨西哥瓜纳华托州各医院的在职护士。通过问卷调查收集人口统计学资料与工作相关信息。采用马斯拉奇职业倦怠量表（Maslach Burnout Inventory, MBI）评估职业倦怠状况。采集血液样本并通过酶联免疫吸附试验（ELISA）技术检测血清sBDNF水平。最终，采用Cognifit©神经心理成套测验的综合认知评估（General Cognitive Assessment, CAB）对认知功能进行评价。

研究结果
结果显示，护士群体中存在与职业倦怠综合征相关的人口统计学特征及工作状态特征。数据分析表明，职业倦怠护士的血清sBDNF水平显著降低，且BDNF水平与职业倦怠综合征呈负相关。此外，此类职业倦怠护士在推理、记忆与注意力维度以及CAB总分上均表现出显著的认知损伤。值得注意的是，本研究还发现职业倦怠护士的血清sBDNF水平与其认知缺陷程度呈正相关。

研究结论
血清BDNF水平降低或可作为职业倦怠的生物学标志物，或是其病理进程的组成部分，进而可能对认知能力造成损害。护士群体的认知功能减退具有重要的临床意义，鉴于护士需针对不断变化的患者病情做出临床决策，因此亟需制定专业化的预防策略。