The appropriate data.

ObjectiveTo assess the diagnostic value of the Copenhagen index for ovarian malignancy.MethodsPubMed, Web of Science, the Cochrane Library, Embase, CBM, CNKI, and WanFang databases were searched throughout June 2021. Statistical analyses were performed using Stata 12, Meta-DiSc, and RevMan 5.3. The pooled sensitivity, specificity, and diagnostic odds ratio were calculated, the summary receiver operating characteristic curve was drawn, and the area under the curve was calculated.ResultsTen articles, including 11 studies with a total of 5266 patients, were included. The pooled sensitivity, specificity, and diagnostic odds ratio were 0.82 [95% CI (0.80–0.83)], 0.88 [95% CI (0.87–0.89)], and 57.31 [95% CI (32.84–100.02)], respectively. The area under the summary receiver operating characteristics curve and the Q index were 0.9545 and 0.8966, respectively.ConclusionOur systematic review shows that the sensitivity and specificity of the Copenhagen index are high enough for it to be used in a clinical setting to provide accurate ovarian cancer diagnosis without considering menopausal status.

研究目的：评估哥本哈根指数（Copenhagen index）对卵巢恶性肿瘤的诊断价值。研究方法：检索截至2021年6月的PubMed、Web of Science、Cochrane图书馆、Embase、中国生物医学文献数据库（CBM）、中国知网（CNKI）及万方数据库。采用Stata 12、Meta-DiSc及RevMan 5.3软件开展统计学分析，计算合并灵敏度、特异度及诊断比值比，绘制汇总受试者工作特征曲线（summary receiver operating characteristic curve）并计算曲线下面积。研究结果：最终纳入10篇文献，涵盖11项研究，共计5266例患者。合并灵敏度、特异度及诊断比值比分别为0.82[95%置信区间（95% CI）：0.80~0.83]、0.88[95%置信区间：0.87~0.89]及57.31[95%置信区间：32.84~100.02]。汇总受试者工作特征曲线下面积及Q指数分别为0.9545与0.8966。研究结论：本系统评价显示，哥本哈根指数的灵敏度与特异度均处于较高水平，无需考虑患者绝经状态即可用于临床卵巢癌的精准诊断。