Transcriptional Repressor BCL6 Maintains Muscle Mass Homeostasis via Negative Feedback Control of Growth Hormone Signaling. Mus musculus

We show that the transcriptional repressor B cell lymphoma 6 (BCL6) is essential for maintaining muscle mass by sustaining GH action. Muscle-specific genetic deletion of BCL6 at either perinatal or adult stages profoundly reduces muscle mass and compromises muscle strength.

本研究证实，转录阻遏蛋白B细胞淋巴瘤6（BCL6）可通过维持生长激素（GH）的作用来维持肌肉质量，是肌肉量维持的必需因子。在围产期或成年阶段实施肌肉特异性BCL6基因敲除，会显著降低肌肉质量并损害肌肉力量。