Synthesis of Lactams via Copper-Catalyzed Intramolecular Vinylation of Amides

Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N‘-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to
seven-membered lactams in moderate to excellent yields.

本研究首次针对碘代烯酰胺（iodoenamides）的铜催化分子内乙烯基化反应展开了探究。以碘化亚铜（CuI）为催化剂、N,N'-二甲基乙二胺（N,N'-dimethylethylenediamine）为配体，多种碘代烯酰胺可在二氧六环（dioxane）中发生环化反应，以中等至优异的收率得到五元至七元环内酰胺。