Table_2_High cholesterol and low triglycerides are associated with total lumbar bone mineral density among adults aged 50 years and over: The NHANES 2017–2020.XLS

BackgroundThe association between cholesterol and triglycerides with the lumbar bone mineral density (BMD) was widely investigated, but the results remained conflicting. This study aimed to investigate the relationship between total cholesterol, triglycerides, and total lumbar BMD in adults.
Materials and methodsThis cross-sectional study included 1,985 individuals aged 50 years and over. The data on total cholesterol, triglycerides, total lumbar BMD, and other covariates were obtained from the National Health and Nutritional (NHANES) between 2017 and March 2020 pre-pandemic. Multivariate logistic regression models were utilized to investigate the association between cholesterol, triglycerides, and total lumbar BMD. Smooth curve fittings and generalized additive models were also used to analyze the potential non-linearity.
ResultsA total of 901 men and 1,084 women with a mean age of 63.02 ± 8.72 years (age 50–80 years) were included in this study. In multivariate regression analysis, the association between cholesterol and total lumbar BMD was negative (β = −0.026, 95% CI: −0.033, −0.020). This relationship still existed after adjusted for gender and race (β = −0.018, 95% CI: −0.025, −0.012) and fully adjusted for all covariates (β = −0.022, 95% CI: −0.029, −0.015). The association between triglycerides and total lumbar BMD was positive (β = 0.024, 95% CI: 0.017, 0.031). This relationship still existed after adjusted for gender and race (β = 0.021, 95% CI: 0.015, 0.028) and fully adjusted for all covariates (β = 0.021, 95% CI: 0.014, 0.028). In threshold effect analysis, the relationship between triglycerides and total lumbar BMD was an inverted U-shaped curve with the inflection point at 2.597 mmol/L.
ConclusionHigh levels of total cholesterol and relatively low levels of triglycerides are significantly associated with the total lumbar BMD in adults aged 50 years and over.

研究背景
胆固醇与甘油三酯和腰椎骨密度（Bone Mineral Density, BMD）之间的关联已被广泛研究，但研究结果仍存在争议。本研究旨在探讨成年人总胆固醇、甘油三酯与腰椎总骨密度的关联。
研究对象与方法
本横断面研究共纳入1985名50岁及以上的受试者。总胆固醇、甘油三酯、腰椎总骨密度及其他协变量的数据来源于2017年至2020年3月新冠疫情大流行前的美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）。本研究采用多因素logistic回归模型分析胆固醇、甘油三酯与腰椎总骨密度的关联；同时通过平滑曲线拟合与广义加性模型，探讨二者间潜在的非线性关联。
研究结果
本研究共纳入901名男性与1084名女性，平均年龄为63.02±8.72岁，年龄范围为50~80岁。多因素回归分析显示，胆固醇与腰椎总骨密度呈负相关（β=-0.026，95%置信区间：-0.033~-0.020）；校正性别与种族后，该关联依然存在（β=-0.018，95%置信区间：-0.025~-0.012），进一步校正所有协变量后，该关联仍具有统计学意义（β=-0.022，95%置信区间：-0.029~-0.015）。甘油三酯与腰椎总骨密度呈正相关（β=0.024，95%置信区间：0.017~0.031）；校正性别与种族后，该关联依然存在（β=0.021，95%置信区间：0.015~0.028），校正所有协变量后，该关联仍显著（β=0.021，95%置信区间：0.014~0.028）。阈值效应分析显示，甘油三酯与腰椎总骨密度的关联呈倒U型曲线，拐点为2.597mmol/L。
研究结论
50岁及以上成年人中，总胆固醇水平升高与甘油三酯水平偏低均与腰椎总骨密度显著相关。