Single-cell RNA Sequencing Facilitates Quantitative Analysis of Fbxw11 overexpressed hematopoietic stem/progenitor cells

We compared the transcriptomic changes in hematopoietic stem/progenitor cells (LSK) when Fbxw11 overexpressed. In order to study the function of Fbxw11 in hematopoietic stem/progenitor cells. Overall design: Hematopoietic stem/progenitor cells were infected with Fbxw11 expressed lentivirus, and compare the transcriptomics changes at single cell level

本研究对比了过表达Fbxw11的造血干/祖细胞（hematopoietic stem/progenitor cells, LSK）的转录组变化，旨在探究Fbxw11在造血干/祖细胞中的功能。整体实验设计：将造血干/祖细胞感染表达Fbxw11的慢病毒，随后在单细胞水平对比其转录组变化。