Mutations in the lacZ gene

This is the raw data representing 6,465 independent lacZ mutations from multiple MutaMouse experiments. We curated lacZ mutations from published studies that were collected using a positive selection assay to identify mutations in lacZ that disrupted β-gal function. These 6,465 independent lacZ mutations cause in 2,732 missense mutations that impair β-gal function. The data were used in a publication on the functional mutational landscape of the lacZ gene.

本数据集为来自多项MutaMouse实验的6465个独立lacZ突变的原始数据。我们从已发表的相关研究中整理得到这些lacZ突变数据，这些研究通过阳性选择筛选实验来识别可破坏β-半乳糖苷酶（β-gal）功能的lacZ突变。在这6465个独立lacZ突变中，共计2732个为可削弱β-半乳糖苷酶功能的错义突变。该数据集曾被用于一项针对lacZ基因功能突变图谱的研究论文。