The urinary microbiome in patients with refractory urge incontinence and recurrent urinary tract infection

Urinary urge incontinence is a chronic, debilitating condition that is difficult to treat. Patients refractory to standard antimuscarinic therapy often experience recurrent urinary tract infections (rUTIs). The microbiota of these refractory patients with rUTI remains unexplored. Here we applied culture-independent sequencing in combination with standard diagnostic microbiology to investigate changes in the urine microbiota of women with urodynamically proven refractory detrusor overactivity and concomitant UTI over a 2-year time period. The data presented here are raw reads from 16S amplicon sequencing.

急迫性尿失禁（Urinary urge incontinence）是一种慢性、衰弱且难治的疾病。对标准抗毒蕈碱治疗（antimuscarinic therapy）耐药的患者常并发复发性尿路感染（rUTIs）。此类合并复发性尿路感染的难治性患者的尿液菌群仍未得到充分探究。本研究采用非培养测序（culture-independent sequencing）结合标准诊断微生物学方法，对经尿动力学证实的难治性逼尿肌过度活动且合并尿路感染的女性患者，在2年随访周期内的尿液菌群变化进行了调查。本数据集所提供的数据为16S扩增子测序（16S amplicon sequencing）的原始读段（raw reads）。