Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

We performed integrative analyses in a Chinese cohort (n = 517) of peri-/post-menopausal women with metagenomics/targeted metabolomics to identify novel microbiome-related biomarkers for bone health. We also performed validations in US Caucasians (n = 59).本研究针对纳入517名围绝经期及绝经后女性的中国队列，开展宏基因组学（metagenomics）/靶向代谢组学（targeted metabolomics）整合分析，以鉴定与骨骼健康相关的新型微生物组（microbiome）相关生物标志物。本研究同时在59名美国白种人群中完成了验证实验。