HCC atlas

To profile the tumor microenvironment (TME) landscape in HCC, we compiled a single-cell atlas with 251,761 cells from 83 donors enrolled in 6 studies. Unsupervised clustering revealed 7 major cell components, including hepatocytes, mesenchymal cells, endothelial cells, myeloid cells, B cells, T cells and NK cells, which were further partitioned through a second round of clustering to generate 53 clusters.

为解析肝细胞癌（Hepatocellular Carcinoma, HCC）的肿瘤微环境（Tumor Microenvironment, TME）全景特征，我们整合了6项研究中83名供体的251761个细胞，构建了单细胞图谱。无监督聚类分析识别出7类主要细胞类群，包括肝细胞、间充质细胞、内皮细胞、髓系细胞、B细胞、T细胞及自然杀伤细胞（Natural Killer, NK）；上述类群经第二轮聚类进一步细分，最终得到53个聚类簇。

搜集汇总

背景与挑战

背景概述

HCC atlas是一个肝细胞癌单细胞RNA测序数据集，包含来自83名捐赠者的251,761个细胞，旨在分析肿瘤微环境。该数据集通过无监督聚类识别出7种主要细胞类型并细分为53个簇，提供了全面的细胞图谱，适用于肿瘤免疫学研究。