Universities of St. Andrews, Dundee, Glasgow, and Aberdeen

The Dundee/St Andrews/Glasgow/Aberdeen BAG research interests fall into two broad areas. Firstly, we use structural information to understand mechanisms of fundamental biological processes, protein engineering, enzymes, and biological chemistry. Secondly, we utilize structural insights to guide target selection and development of lead compounds for drug development. Fundamental insights obtained into biological processes are often closely coupled to target identification and development of tools, reagents, or inhibitors, which feed into a range of biomedical applications. Our research relies heavily on high quality, reliable and tunable synchrotron radiation, along with state-of-the-art optics, detectors, sample changers, and computation, to support determination of new structures, as well as collect high resolution diffraction data to provide the level of accuracy important in structure-guided drug design.

邓迪/圣安德鲁斯/格拉斯哥/阿伯丁BAG的研究兴趣分为两大领域。其一，我们利用结构信息解析基础生物过程、蛋白质工程、酶学及生物化学的机制；其二，我们借助结构洞察指导药物开发中的靶点选择与先导化合物研发。对生物过程获得的基础认知往往与靶点识别、工具/试剂或抑制剂的开发紧密关联，进而应用于一系列生物医学场景。我们的研究高度依赖高质量、可靠且可调的同步辐射，以及最先进的光学器件、探测器、样品转换器和计算技术，以支持新结构的测定，并收集高分辨率衍射数据，从而为结构引导药物设计提供关键的准确性保障。