Table_1_Association between radiotherapy for surgically treated oral cavity cancer and secondary lung cancer.pdf

BackgroundThere is limited research on the incidence of secondary lung cancer (SLC) after radiotherapy (RT) for oral cavity cancer (OCC). Therefore, we investigated the association between RT for OCC and the risk of SLC and the overall survival of these patients.
MethodsPatients diagnosed with OCC between 1975 and 2015 were selected from the Surveillance, Epidemiology, and End Results database. The cumulative incidence of SLC, relative risk (RR) of RT vs. no RT (NRT), standardized incidence ratios (SIR), and survival outcomes were assessed.
ResultsA total of 10,936 patients with OCC were included. Of these, 429 (3.92%) patients developed SLC, where 136 (5.02%) received RT and 293 (3.56%) did not. The cumulative incidence of SLC during follow-up was 6.89% and 4.84% in the RT and NRT patients, respectively. RT was associated with a higher risk of SLC. In the subset analysis, the results showed that a higher risk of developing SLC among patients with index OCC in most subgroups. Dynamic RR and SIR revealed a decreased risk of SLC with increasing latency time. No difference was observed in the 10-year survival rates for patients with SLC who received RT or not or compared with primary lung cancer.
ConclusionRT was associated with a higher risk of SLC, and patients diagnosed with OCC could be followed for 5–10 years after diagnosis.

Background 目前针对口腔癌（oral cavity cancer, OCC）放疗（radiotherapy, RT）后继发性肺癌（secondary lung cancer, SLC）的发病率相关研究较为有限。为此，本研究旨在探讨口腔癌放疗与继发性肺癌发病风险及患者总生存情况之间的关联。
Methods 研究对象选自监测、流行病学与最终结果（Surveillance, Epidemiology, and End Results, SEER）数据库中1975年至2015年确诊的口腔癌患者。本研究评估了继发性肺癌的累积发病率、放疗组与未放疗组的相对风险（relative risk, RR）、标准化发病比（standardized incidence ratios, SIR）以及生存结局。
Results 本研究共纳入10936例口腔癌患者，其中429例（3.92%）发生继发性肺癌，放疗组与未放疗组分别有136例（5.02%）与293例（3.56%）出现继发性肺癌。随访期间，放疗组与未放疗组患者的继发性肺癌累积发病率分别为6.89%与4.84%。放疗与继发性肺癌发病风险升高显著相关。亚组分析结果显示，多数原发口腔癌亚组患者的继发性肺癌发病风险均有所升高。动态相对风险与标准化发病比分析显示，随着发病潜伏期的延长，继发性肺癌的发病风险呈下降趋势。无论继发性肺癌患者是否接受放疗，其10年生存率均无显著差异；且该类患者的10年生存率与原发性肺癌患者相比亦无明显区别。
Conclusion 本研究结果表明，口腔癌放疗与继发性肺癌发病风险升高相关，确诊口腔癌的患者应在确诊后5至10年内开展随访监测。