Systemic sarcoidosis presenting as acute rapidly progressive proptosis

ABSTRACT Sarcoidosis is a generalized systemic chronic inflammation that rarely involves the orbit. As a chronic inflammation, sarcoidosis typically manifests with an insidious onset and slowly progressive course. We report a case of acute-onset proptosis resulting from a rapidly growing diffuse orbital mass that simulated malignant growth, which was biopsy proven to be the first manifestation of systemic sarcoidosis. The patient demonstrated complete resolution of proptosis and systemic involvement with long-term corticosteroid treatment.

摘要
结节病（Sarcoidosis）是一种全身性慢性炎症性疾病，极少累及眼眶。作为一种慢性炎症性疾病，结节病通常起病隐匿，病程呈缓慢进行性发展。本次报告1例因快速生长的弥漫性眼眶肿物引发急性起病眼球突出（proptosis）的病例，该肿物酷似恶性病变，后经活检证实为全身性结节病的首发临床表现。该患者经长期糖皮质激素治疗后，眼球突出及全身受累症状均完全缓解。