Phylogenetically diverse HPC statistics per inhibitor.

For each inhibitor, the total number of true -HPCs (column “# true -HPCs”) is shown. The subset of true -HPCs that consist of proteins from two or more of the kinase families defined by Manning et al. [2] (column “# families”) are also shown. The multitude of true -HPCs that include proteins from distinct families of the kinome can be noted by the relatively large percentage (73% overall across all inhibitors) of HPCs that span families. All of these 41964 instances of structurally similar features between families are provided in Dataset S1.

针对每一种抑制剂，均给出了真-HPCs（true-HPCs）的总数量，对应数据列标注为"# true -HPCs"。同时还列出了由Manning等人[2]所定义的、包含两类及以上激酶家族蛋白的真-HPCs子集，对应数据列标注为"# families"。值得注意的是，跨家族的HPCs占比高达73%（所有抑制剂的整体统计值），这一可观比例充分体现了激酶组不同家族间存在大量此类真-HPCs。所有这41964个家族间结构相似特征的实例均已收录于数据集S1（Dataset S1）中。