Data_Sheet_1_Atherogenic Index of Plasma and Coronary Artery Disease in the Adult Population: A Meta-Analysis.docx

Background: The atherogenic index of plasma (AIP), which is the logarithm of the ratio between the triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) concentrations in molar units, is correlated with the burden of atherosclerosis. This study aimed to evaluate the association between the AIP and coronary artery disease (CAD) in the adult population by performing a meta-analysis.
Methods: Observational studies relevant for this meta-analysis were identified by searching the PubMed, Embase, and Web of Science databases. Only studies using multivariate analysis were considered. A random-effects model, which incorporates potential intra-study heterogeneity, was applied to combine the results.
Results: Ten observational studies were included. In studies with the AIP analyzed as a continuous variable, a higher AIP was associated with a higher odds of CAD (adjusted risk ratio [RR] per 1-standard deviation [SD] increment of AIP: 2.10, 95% confidence interval [CI]: 1.51–2.93, P < 0.001, I2 = 90%). Further analysis of studies with the AIP analyzed as a categorical variable showed a higher odds of CAD (adjusted RR: 2.35, 95% CI: 1.88–2.93, P < 0.001, I2 = 37%) in the participants with the highest versus the lowest AIP value. Subgroup analyses demonstrated consistent results in asymptomatic and symptomatic populations as well as in male and female participants (all between-group P values > 0.05).
Discussion: Current evidence, mostly from cross-sectional studies, suggests that a higher AIP value may be independently associated with CAD in the adult population.

背景：血浆致动脉粥样硬化指数（atherogenic index of plasma, AIP）为摩尔单位下甘油三酯与高密度脂蛋白胆固醇浓度比值的对数，与动脉粥样硬化负荷相关。本研究旨在通过开展荟萃分析，评估成人人群中AIP与冠状动脉疾病（coronary artery disease, CAD）的关联。
方法：通过检索PubMed、Embase及Web of Science数据库，筛选出与本荟萃分析相关的观察性研究。仅纳入采用多变量分析的研究。采用可纳入潜在研究内异质性的随机效应模型合并研究结果。
结果：共纳入10项观察性研究。在将AIP作为连续变量分析的研究中，AIP水平升高与冠状动脉疾病发生风险升高相关（AIP每增加1个标准差（standard deviation, SD）的校正后风险比（risk ratio, RR）为2.10，95%置信区间（confidence interval, CI）：1.51~2.93，P < 0.001，I² = 90%）。进一步对将AIP作为分类变量分析的研究进行分析显示，与AIP最低组受试者相比，AIP最高组受试者的冠状动脉疾病发生风险更高（校正后RR：2.35，95%CI：1.88~2.93，P < 0.001，I² = 37%）。亚组分析显示，在无症状与有症状人群以及男性、女性受试者中均得到一致结果（所有组间P值均>0.05）。
讨论：现有证据（主要来自横断面研究）表明，成人人群中更高的AIP水平可能与冠状动脉疾病独立相关。