Table_1_Association between Life’s simple 7 and rheumatoid arthritis in adult Americans: data from the National Health and nutrition examination survey.DOCX

ObjectiveThe study aimed to investigate the relationship between Life’s Simple 7 (LS7) and the risk of rheumatoid arthritis (RA) in adult Americans.
MethodsA total of 17,532 participants were included in this study. The association between LS7 and the risk of RA was assessed using a weighted logistic regression model, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated. Moreover, the nonlinear relationship was further characterized through smooth curve fitting (SCF) and weighted generalized additive model (GAM) analysis.
ResultsAfter adjusting for all covariates, the weighted logistic regression model demonstrated that the LS7 was negatively correlated with the risk of RA. Compared to quintile 1 of LS7, the OR between the risk of RA and quartile 4 of LS7 (LS7.Q4) was 0.261 (95% CI, 0.203, 0.337) in males under 50 years old, while in females of the same age group, the OR was 0.183 (95% CI, 0.142, 0.234). For females aged between 50 and 70 years old, the OR between the risk of RA and LS7.Q4 was 0.313 (95% CI, 0.264, 0.371). In females aged 70 years or older, the OR between the risk of RA and LS7.Q4 was 0.632 (95% CI, 0.486, 0.822).
ConclusionThis finding suggested the healthy lifestyle behaviors represented by LS7 have a negative association with RA. However, further prospective studies are needed to verify the causal relationship in the results.

研究目的 本研究旨在探究美国成年人群中简易生活方式7项指标（Life’s Simple 7，LS7）与类风湿关节炎（rheumatoid arthritis，RA）发病风险的关联。
研究方法 本研究共纳入17532名研究对象。采用加权logistic回归模型（weighted logistic regression model）分析LS7与RA发病风险的关联，计算比值比（odds ratios，ORs）与95%置信区间（95% confidence intervals，CIs）。此外，通过平滑曲线拟合（smooth curve fitting，SCF）与加权广义加性模型（weighted generalized additive model，GAM）进一步刻画二者间的非线性关联。
研究结果 在校正所有混杂因素后，加权logistic回归模型结果显示，LS7与RA发病风险呈负相关。以LS7五分位第1组为参照，50岁以下男性人群中，LS7四分位第4组（LS7.Q4）对应的RA发病风险OR值为0.261（95%CI：0.203~0.337）；同年龄段女性人群的OR值为0.183（95%CI：0.142~0.234）。50~70岁女性人群中，LS7.Q4对应的RA发病风险OR值为0.313（95%CI：0.264~0.371）；70岁及以上女性人群的OR值为0.632（95%CI：0.486~0.822）。
研究结论 本研究结果提示，以LS7为代表的健康生活方式行为与RA发病风险呈负相关。但仍需开展进一步的前瞻性研究以验证本研究结果中的因果关联。