The effects of resistance training on myostatin in Older Adults with Frailty and/or Sarcopenia

To systematically evaluate the effects of resistance training (RT) on myostatin (MSTN) levels in older adults with frailty and/or sarcopenia.We systematically searched electronic databases including PubMed, Web of Science, and the Cochrane Library for randomized controlled trials (RCTs) investigating the effects of RT on MSTN levels in older adults with frailty/sarcopenia, from database inception to March 2025. Two reviewers independently performed literature screening, data extraction, and assessed the risk of bias using the Cochrane Risk of Bias tool. Meta-analysis was conducted using Stata software.

本研究旨在系统评估抗阻训练（RT）对衰弱和/或肌少症老年人群肌抑素（MSTN）水平的影响。我们系统检索了PubMed、Web of Science及考克兰图书馆等电子数据库，检索时限自建库起至2025年3月，纳入探究抗阻训练对衰弱和/或肌少症老年人群肌抑素水平影响的随机对照试验（RCTs）。由2名评价者独立完成文献筛选、数据提取，并采用考克兰偏倚风险工具评估纳入研究的偏倚风险。本研究采用Stata软件开展荟萃分析。